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美国佐治亚州立大学Yi Jiang教授学术报告

信息来源: 暂无 发布日期: 2018-06-29 浏览次数:

报告题目:The  Shapes of Cell Migration

报告人:Yi  Jiang,教授,美国佐治亚州立大学

报告时间:2018年7月3日上午,10:00--11:30

报告地点:数计学院4号楼229会议室

报告摘要:Biologists and pathologists have long relied on  cell shape to discern cell phenotypes and states, but the underlying premise of  this practice has not been quantitatively tested. Here we show, using cell  migration as an example, that a single cell image projected to a low-dimensional  shape space can discriminate migration behavior. Cell shape, determined by the  interaction of many elements such as the cytoskeleton, cell membrane and  adhesion to the substrate and other cells, changes during migration. We analyzed  a large number of 2D cell migration images over time and found that the cell  shape variation space is low dimensional, and migration behavior can be  determined by the coordinates of a single cell image in the low dimensional  shape space. We further show that this is possible because persistent cell  migration is characterized with long persistence time, low speed variation,  spatial-temporally coordinated protrusion and contraction, and a different  distribution signature in the cell shape-space. Our findings provide a  quantitative underpinning for that a static cell image can discriminate  dynamical behavior.