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台湾清华大学何宗易教授学术报告

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Talk 1:Digital  Microfluidic Biochips: Towards Hardware/Software Co-Design and Cyberphysical  System Integration

报告时间:2016年9月6号,9am-10:30am

报告地点:数计学院4号楼第2报告厅

Abstract: Advances in droplet-based digital microfluidic biochips  (DMFBs) have led to the emergence of biochips for automating laboratory  procedures in biochemistry and molecular biology. These devices enable the  precise control of microliter of nanoliter volumes of biochemical samples and  reagents. They combine electronics with biology, and integrate various bioassay  operations, such as sample preparation, analysis, separation, and detection. To  meet the challenges of increasing design complexity and precision, the interplay  between hardware and software through sensor-based cyberphysical integration  will be involved to build DMFBs effectively. This talk offers attendees an  opportunity to bridge the semiconductor ICs/system industry with the biomedical  and pharmaceutical industries. The talk will first describe emerging  applications in biology and biochemistry that can benefit from advances in  electronic "biochips". The presenter will next describe technology platforms for  accomplishing "biochemistry on a chip", and introduce the audience to  microarrays and fluidic actuation methods based on microfluidics. The  droplet-based "digital" microfluidic platform based on electrowetting will be  described in considerable detail. Next, the presenter will describe fabrication  techniques for digital microfluidic biochips, followed by computer-aided design,  design-for-testability, cyberphysical integration, and reconfiguration aspects  of chip/system design. Synthesis algorithms and methods will be presented to map  behavioral descriptions to a digital microfluidic platform, and generate an  optimized schedule of bioassay operations, chip layout, and droplet-flow paths.  In this way, the audience will see how a "biochip compiler" can translate  protocol descriptions provided by an end user (e.g., a chemist or a nurse at a  doctor's clinic) to a set of optimized and executable fluidic instructions that  will run on the underlying digital microfluidic  platform.


Talk 2:  The Coming of  Age of Flow-Based Microfluidics: EDA Solutions for Enabling Biochemistry on a  Chip

报告时间:2016年9月6号,2:30pm-4:00pm

地点:数计学院4号楼第2报告厅

Abstract:  As the design complexity rapidly increases, the  manufacture and the biochemical analysis of flow-based microfluidic biochip  become more complicated. According to recent study, the biochips can now use  more than 25,000 valves and about a million features to run 9,216 parallel  polymerase chain reactions. Moreover, the number of mechanical valves per square  inch for flow-based microfluidic biochips has grown exponentially and four times  faster than the reflection of Moore's Law. Although the scale for flow-based  microfluidic biochips is enlarging and the total amount of the valves fabricated  on a chip are also growing significantly, computer-aided design (CAD) tools are  still in their infancy today. Designers are using bottom-up full-custom design  approaches involving multiple non-automated steps to manually adjust the  components and the connection to satisfy the steps of desired biochemical  applications. As a result, the development of explicit design rules and  strategies allowing modular top-down synthesis methodologies are needed, in  order to provide the same level of CAD support for the biochip designer as the  one that are currently done for the semiconductor industry. This talk will offer  attendees an opportunity to bridge the semiconductor ICs/system industry with  the biomedical and pharmaceutical industries. The talk will first describe  emerging applications in biology and biochemistry that can benefit from advances  in electronic “biochips”. The presenter will next describe technology platforms  for accomplishing “biochemistry on a chip”, and introduce the audience to  flow-based “continuous” microfluidics based on microvalve technology. Next, the  presenter will describe system-level synthesis includes operation scheduling and  resource binding algorithms, and physical-level synthesis includes placement and  routing optimizations. In this way, the audience will see how a “biochip  compiler” can translate protocol descriptions provided by an end user (e.g., a  chemist or a nurse at a doctor’s clinic) to a set of optimized and executable  fluidic instructions that will run on the underlying microfluidic platform.  Testing techniques will be described to detect faults after manufacture and  during field operation. A classification of defects will be presented based on  data for fabricated chips. Appropriately fault models will be developed and  presented to the audience. Finally, a number of case studies with recent  applications on flow-based microfluidic biochips such as antibiotic  susceptibility test will be discussed. Future challenges and several open  problems in this area will also be presented.

Speaker  Bio: Tsung-Yi Ho received his Ph.D. in Electrical Engineering  from National  Taiwan University in 2005. He is a Professor with  the Department of Computer Science of National Tsing Hua University, Hsinchu,Taiwan. His research interests  include design automation and test for microfluidic biochips and nanometer  integrated circuits. He has presented 10 tutorials and contributed 10 special  sessions in ACM/IEEE conferences, all in design automation for microfluidic  biochips. He has been the recipient of the Invitational Fellowship of the Japan  Society for the Promotion of Science (JSPS), the Humboldt Research Fellowship by  the Alexander von Humboldt Foundation, and the Hans Fischer Fellow by the  Institute of  Advanced Study of the  Technical University of Munich, Germany. He was a recipient of the Best Paper  Awards at the VLSI Test Symposium (VTS) in 2013 and IEEE Transactions on  Computer-Aided Design of Integrated Circuits and Systems in 2015. He served as a  Distinguished Visitor of the IEEE Computer Society for 2013-2015, the Chair of  the IEEE Computer Society Tainan Chapter for 2013-2015, and the Chair of the ACM  SIGDA Taiwan Chapter for 2014-2015. Currently he serves as an ACM Distinguished  Speaker, a Distinguished Lecturer of the IEEE Circuits and Systems Society, and  Associate Editor of the ACM Journal on Emerging Technologies in Computing  Systems, ACM Transactions on Design Automation of Electronic Systems, IEEE  Transactions on Computer-Aided Design of Integrated Circuits and Systems, and  IEEE Transactions on Very Large Scale Integration Systems, Guest Editor of IEEE  Design & Test of Computers, and the Technical Program Committees of major  conferences, including DAC, ICCAD, DATE, ASP-DAC, ISPD, ICCD,  etc.