首 页 中心简介 成员介绍 学术交流 教育部重点实验室 科研动态 研究生培养 省数学会 English
发表日期:2018年6月29日      

美国佐治亚州立大学Yi Jiang教授学术报告

 

报告题目:The Shapes of Cell Migration

报告人:Yi Jiang,教授,美国佐治亚州立大学

报告时间:2018年7月3日上午,10:00--11:30

报告地点:数计学院4号楼229会议室

 

报告摘要:Biologists and pathologists have long relied on cell shape to discern cell phenotypes and states, but the underlying premise of this practice has not been quantitatively tested. Here we show, using cell migration as an example, that a single cell image projected to a low-dimensional shape space can discriminate migration behavior. Cell shape, determined by the interaction of many elements such as the cytoskeleton, cell membrane and adhesion to the substrate and other cells, changes during migration. We analyzed a large number of 2D cell migration images over time and found that the cell shape variation space is low dimensional, and migration behavior can be determined by the coordinates of a single cell image in the low dimensional shape space. We further show that this is possible because persistent cell migration is characterized with long persistence time, low speed variation, spatial-temporally coordinated protrusion and contraction, and a different distribution signature in the cell shape-space. Our findings provide a quantitative underpinning for that a static cell image can discriminate dynamical behavior.




相关信息:
 没有相关信息

 
 
 

| 加入收藏 | 设为首页 | 管理系统 |


版权所有: 福州大学离散数学与理论计算机科学研究中心
地址:福建省福州市福州地区大学新区学园路2号   邮编:350116
联系电话: 0591-83058092 ,83846655
传真:0591-83846622  E-mail: dimacs@fzu.edu.cn